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Single‐Atom Nanozyme for Wound Antibacterial Applications, ANGEW CHEM INT EDIT, 29 Jan 2019
2019-02-15 | 【     】【打印】【关闭

Angewandte Chemie International Edition, 29 January, 2019, DOI: https://doi.org/10.1002/anie.201813994

Single‐Atom Nanozyme for Wound Antibacterial Applications

Bolong Xu, Hui Wang, Weiwei Wang, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang, Hailong Yang, Xiangqin Meng, Qiuwen Wu, Lirong Zheng, Shenming Chen, Xinghua Shi, Kelong Fan, Xiyun Yan, Huiyu Liu

Abstract

The single‐atom catalysts (SACs) as homogeneous catalysts have been widely explored for chemical catalysis. However, few studies focus on SACs' applications in enzymatic catalysis. Herein, we first report that a zinc‐based zeolitic?imidazolate‐frameworks (ZIF‐8) derived carbon nanomaterial containing atomically dispersed zinc atoms could serve as a highly efficient single‐atom peroxidase mimic. To reveal its structure‐activity relationship, we systematically investigated the structural evolution of SAzyme. In addition, the coordinatively unsaturated active zinc sites and catalytic mechanism of SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme with high therapeutic effect and biosafety shows great promises for wound antibacterial applications.

文章链接:https://onlinelibrary.wiley.com/doi/10.1002/anie.201813994

相关报道:www.ibp.cas.cn/kyjz/zxdt/201902/t20190215_5240477.html

 

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